Neuregulin-1 modulates right ventricle cardiomyocyte function in pulmonary arterial hypertension
نویسندگان
چکیده
منابع مشابه
The right ventricle in pulmonary arterial hypertension.
Pulmonary arterial hypertension (PAH) is a right heart failure syndrome. In early-stage PAH, the right ventricle tends to remain adapted to afterload with increased contractility and little or no increase in right heart chamber dimensions. However, less than optimal right ventricular (RV)-arterial coupling may already cause a decreased aerobic exercise capacity by limiting maximum cardiac outpu...
متن کاملRight Atrial Function in Pulmonary Arterial Hypertension.
BACKGROUND Elevated right atrial (RA) pressure is an established prognostic measure in pulmonary arterial hypertension (PAH). However, little is known about perturbations in RA function in PAH. METHODS AND RESULTS Reservoir (RA longitudinal strain [RA LS]), conduit (RA early LS rate), and active (RA late LS rate) phases were assessed by 2D speckle tracking in 65 patients with PAH, 6-minute wa...
متن کاملThe role of the right ventricle in pulmonary arterial hypertension.
Although changes in the pulmonary vasculature are the primary cause of pulmonary arterial hypertension (PAH), severity of symptoms and survival are strongly associated with right ventricular function, and right heart failure is the main cause of death in patients with PAH. Echocardiography and cardiac magnetic resonance imaging allow noninvasive evaluation of right ventricular function and stru...
متن کاملRelationship between pulmonary artery hemodynamics and right ventricle function in pulmonary arterial hypertension using cardiovascular magnetic resonance
A comprehensive CMR exam was developed for evaluating right ventricle (RV) and pulmonary artery (PA), and was tested on 25 PA hypertension (PAH) patients. Standard non-CMR measurements were also collected. Comprehensive statistical analysis was conducted to study relationships between parameters, parameters’ significance, and data redundancy and reduction. The results showed strong correlations...
متن کاملProtein Changes Contributing to Right Ventricular Cardiomyocyte Diastolic Dysfunction in Pulmonary Arterial Hypertension
BACKGROUND Right ventricular (RV) diastolic function is impaired in patients with pulmonary arterial hypertension (PAH). Our previous study showed that elevated cardiomyocyte stiffness and myofilament Ca(2+) sensitivity underlie diastolic dysfunction in PAH. This study investigates protein modifications contributing to cellular diastolic dysfunction in PAH. METHODS AND RESULTS RV samples from...
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2013
ISSN: 0195-668X,1522-9645
DOI: 10.1093/eurheartj/eht310.p5029